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盘点 ARVO 2026 :干眼病研究专题分析报告

   日期:2026-05-12 17:27:50     来源:网络整理    作者:本站编辑    评论:0    
盘点 ARVO 2026 :干眼病研究专题分析报告

全球眼科领域的年度盛会 —— ARVO 2026 已圆满落幕。该会议汇聚顶尖科研成果,其中干眼病(DED) 是关注度极高的核心议题。为帮助大家快速把握行业脉搏,特别整理这份专题分析,深度复盘 ARVO 2026 上干眼病领域的核心进展与未来趋势。

第一部分文章分类

本次ARVO年会标题含 “dry eye” 的文章共约145篇,按研究类型分为以下五大类别。

一、基础机制 & 动物实验

涵盖免疫炎症机制(Treg/Th17轴、巨噬细胞极化、外泌体)、单细胞与空间转录组学、神经免疫与神经机制、脂质代谢、干细胞治疗、分子信号通路及各类动物模型(基因敲除、BAC诱导、SS模型等)。本类是数量最多的研究方向,体现出基础研究的高度活跃。

英文标题

中文标题

Brachyspira Extracellular Vesicles Promote M2 Macrophage Polarization and Preserve Ocular Surface Homeostasis in Dry Eye

短螺旋体胞外囊泡促进巨噬细胞 M2 型极化并维持干眼眼表稳态

A novel autoimmune mouse model for Sjögren’s Syndrome-related dry eye

一种新型干燥综合征相关性干眼自身免疫小鼠模型

The neuroimmune status of an emerging murine model of evaporative dry eye disease (Awat2 knockout mice)

新型蒸发过强型干眼小鼠模型(Awat2 基因敲除小鼠)的神经免疫状态

Persistent Treg Dysfunction Drives Memory Th17 Reactivation in Chronic Dry Eye Disease

持续性调节性 T 细胞功能异常驱动慢性干眼患者记忆性 Th17 细胞再活化

Single-cell transcriptomic deconvolution of the ocular surface microenvironment in autoimmune-mediated dry eye disease

自身免疫性干眼眼表微环境的单细胞转录组反卷积分析

Effects of PRP and CM-ADSC on Corneal Epithelial Wound Healing in a Murine Dry Eye Model

富血小板血浆与脂肪间充质干细胞条件培养基对干眼小鼠角膜上皮创伤愈合的作用

Spatial transcriptomic analysis of the aging human lacrimal gland: Insights into dry eye disease and glandular dysfunction

衰老人泪腺的空间转录组分析:对干眼及腺体功能障碍的机制启示

Characterization of Human Corneal Epithelial and Meibomian Gland Epithelial Cells in a Hyperosmolar Dry Eye Disease Model

高渗透压干眼模型中人角膜上皮与睑板腺上皮细胞的特征研究

Topical clusterin treatment restores ocular surface homeostasis in dry eye through p38 MAPK signaling pathway

局部施用丛生蛋白通过 p38 MAPK 信号通路恢复干眼眼表稳态

Exosomes from Interleukin 35-producing B cells (i35-Bregs) ameliorate GVHD and Benzalkonium chloride induced dry eye disease

分泌 IL-35 的调节性 B 细胞外泌体改善移植物抗宿主病及苯扎氯铵诱导性干眼

Immune-competent human conjunctival in vitro model to advance Dry Eye Disease research

用于干眼机制研究的具有免疫活性的人结膜体外模型

Contribution of sympathetic nerve activation to the pathogenesis of Sjögren’s syndrome-associated dry eye via NE-Adra1a pathway

交感神经激活通过去甲肾上腺素 - Adra1a 通路参与干燥综合征相关性干眼发病机制

Single-Cell Transcriptomic Analysis Reveals the Anti-Inflammatory Effects of Butyrate in Autoimmune Dry Eye Disease

单细胞转录组分析揭示丁酸盐对自身免疫性干眼的抗炎作用

Exploring the contribution of Zeis gland secretions to the tear film and their implications in Demodex Blepharitis and Dry Eye Disease

蔡氏腺分泌物对泪膜的作用及其在蠕形螨睑缘炎和干眼中的意义

Multimodal Mechanisms of Streptococcus thermophilus iHA318 in Alleviating Dry Eye Symptoms: Neural Regulation, Inflammasome Inhibition, and Mucin Sialylation

嗜热链球菌 iHA318 缓解干眼症状的多模态机制:神经调控、炎症小体抑制及黏蛋白唾液酸化

Single-Cell Transcriptome Sequencing Reveals the Mechanism of Oxidative Stress in Lacrimal Acinar Cells Triggering Dry Eye

单细胞转录组测序揭示泪腺腺泡细胞氧化应激诱发干眼的机制

Comparative Analysis of Clinical and Antioxidant-Related Parameters Following Oral and Topical Administration of Bd SOD in a Murine Dry Eye Model

口服与局部应用 Bd 超氧化物歧化酶对干眼模型临床及抗氧化指标的对比分析

Sex-specific differences in ocular surface damage in a benzalkonium chloride-induced murine model of dry eye disease

苯扎氯铵诱导干眼模型眼表损伤的性别差异

Efficacy of ocular surface immune globulins in models for dry eye disease

眼表免疫球蛋白在干眼模型中的治疗疗效

Comparative Efficacy of Cyclosporine and Lifitegrast in Various Mouse Models of Dry Eye Disease

环孢素与利福特拉斯在多种干眼小鼠模型中的疗效对比

Direct correlation of levels of meibum cholesteryl ester, hydrocarbon chain saturation and protein with lipid structure, in relation to age and dry eye disease.

睑板腺胆固醇酯、碳链饱和度、蛋白水平与脂质结构的直接关联及年龄、干眼的影响

CSBF as an Endogenous Protective Factor and a Novel Therapeutic Candidate for Dry Eye Disease

CSBF 作为干眼内源性保护因子及新型潜在治疗靶点

Thealoz® Total Reduces Corneal Damage and Complement System Activation in a Murine Model of Severe Dry Eye Disease

Thealoz® Total 可减轻重度干眼小鼠角膜损伤并抑制补体系统激活

STLR-201 restores corneal integrity in mouse models of dry eye: a cell-free biologic therapy for Sjögren dry eye

STLR-201 修复干眼小鼠角膜完整性:一种治疗干燥综合征干眼的无细胞生物疗法

Excessive capsaicin intake leads to a dry eye status characterized by corneal nerve degeneration and lacrimal gland impairment that can be alleviated by suppression of TRPV-1 activation with L-carnitine

过量辣椒素摄入诱发以角膜神经退行性变、泪腺损伤为特征的干眼,左卡尼汀抑制 TRPV-1 活化可缓解该病变

Spheroid Assembly of Mesenchymal Stem Cells Enhances Secretome-Mediated Corneal Reinnervation and Epithelial Repair in a Mouse Model of Experimental Dry Eye

间充质干细胞球体培养通过分泌组增强干眼小鼠角膜神经再生与上皮修复

Age-related dry eye is associated with abnormal lipid metabolism and the formation of lipid-laden cysts in lacrimal glands

年龄相关性干眼与泪腺脂质代谢异常及脂质囊泡形成相关

Treating experimental dry eye disease with growth hormone-releasing hormone receptor inhibition

抑制生长激素释放激素受体用于实验性干眼治疗

FAM19A4: An Immunomodulator Promoting Tissue Repair in Dry Eye Disease

FAM19A4:一种可促进干眼组织修复的免疫调节因子

Peroxiredoxin 5 Knock-Out (Prdx5 KO) Mice Exhibit Increased Susceptibility to Dry Eye Disease through Pathophysiological Changes in the Ocular Surface System

过氧化物还原酶 5 基因敲除小鼠通过眼表病理生理改变增加干眼易感性

STLR-201 promotes corneal epithelial growth in vitro: a cell-free biologic therapy for Sjögren dry eye

STLR-201 体外促进角膜上皮生长:治疗干燥综合征干眼的无细胞生物疗法

Targeting retinoid metabolism to mitigate corneal damage in dry eye disease

靶向维 A 酸代谢通路减轻干眼角膜损伤

Topical Application of Low-Concentration IL-2 Enhances Treg's Function and Plays Anti-Inflammatory Roles in Experimental Dry Eye Disease

低浓度 IL-2 局部应用增强调节性 T 细胞功能并对实验性干眼发挥抗炎作用

Th17 cells induce Direct Epithelial Damage via an IL-17A–Dependent Mechanism in an Experimental Dry Eye Disease Model

Th17 细胞通过 IL-17A 依赖机制直接造成实验性干眼角膜上皮损伤

二、临床危险因素 & 流行病学

涵盖环境因素(空气污染/黑碳、城市绿地、气温、二手烟)、遗传学(多基因风险评分、双生子遗传度)、药物暴露(维A酸类)、生活方式(屏幕使用)、全球疾病负担及疾病进展预测模型等。

英文标题

中文标题

Prior Isotretinoin Exposure and Meibomian Gland Dysfunction in a Dry Eye Clinic Population: A Cross-Sectional Study

干眼门诊人群既往异维 A 酸暴露史与睑板腺功能障碍的相关性:一项横断面研究

Economic Burden of Dry Eye Disease in India: A Systematic Review and Meta-Analysis

印度干眼疾病的经济负担:系统综述与 Meta 分析

The impact of second-hand smoking on dry eye prevalence and severity: A population-based study in Hong Kong

二手烟暴露对干眼患病率及严重程度的影响:香港一项基于人群的研究

Long-term Black Carbon Exposure, Residential Greenness, and Dry Eye Disease Risk: A Case-Control Study

长期黑碳暴露、居住地绿地覆盖率与干眼发病风险:一项病例对照研究

Genetic Predisposition to Dry Eye Disease: Polygenic Risk Scores in Miami Veterans

干眼的遗传易感性:迈阿密退伍军人多基因风险评分研究

Predicting Dry Eye Disease and Identifying Serum Metabolic Signatures with Machine Learning

基于机器学习预测干眼发病并筛选血清代谢标志物

Association between dry eye disease and temperature is modified by residential greenness: A Case-crossover study in Beijing

居住地绿地覆盖率调节干眼与环境温度的关联:北京一项病例交叉研究

Prevalence and associated risk factors of symptomatic dry eye in a Ghanaian student population

加纳学生群体有症状干眼患病率及相关危险因素

Risk of Dry Eye Syndrome and Meibomian Gland Dysfunction Following Retinoid Use: a National Multicenter Database Study

 A 酸类药物使用与干眼、睑板腺功能障碍发病风险:全国多中心数据库研究

Developing a prediction model for dry eye disease progression: An electronic health record - based study

构建干眼疾病进展预测模型:基于电子病历的研究

Global Unmet Needs in Dry Eye: A Comparative Assessment Across the United States and Five International Populations

全球干眼临床未满足医疗需求:美国及五个国家人群对比评估

Correlation and prevalence of dry eye disease, digital eye strain, vision-related quality of life and digital screen use in office workers.

职场人群干眼、视疲劳、视觉相关生活质量与电子屏幕使用的患病率及相关性

Huddersfield Dry eye and Myopia Study- Baseline preliminary results

哈德斯菲尔德干眼与近视研究:基线初步结果

Quantitative Dose-Response Modeling of Spaceflight Radiation and Risk of Astronaut Spaceflight-Associated Dry Eye Syndrome (SADES)

航天辐射与航天员航天相关性干眼综合征发病风险的定量剂量反应模型

Heritability of dry eye traits measured by ocular surface analyzer in an unselected twin cohort

基于眼表分析仪的干眼表型在普通双生子队列中的遗传度研究

Predicting OSDI6-Defined Symptomatic Dry Eye in Mexican University students Using Lifestyle and Clinical Characteristics: A Machine-Learning Approach

基于生活方式与临床特征机器学习模型预测墨西哥大学生 OSDI6 定义的症状性干眼

三、诊断评估 & 检查新技术

涵盖AI/深度学习辅助诊断(睑板腺成像、结膜充血分割、眨眼分析)、微流控泪液流变技术、移动端APP、神经功能评估与生物标志物(泪液皮质醇、谷氨酸、PDGF、IL-18/NETosis)、质谱脂质组学、眼表分析仪及诊断指标比较研究。

英文标题

中文标题

Tear Levels of Cortisol in Healthy Subjects and in Patients with Different Severity Grades of Dry Eye Disease

健康人群及不同严重程度干眼患者的泪液皮质醇水平

BiLSTM-based segmentation of blink phases from vertical EOG in normal and dry eye subjects

基于双向长短期记忆网络的正常人与干眼受试者垂直眼电信号眨眼时相分割

A Single-Neuron Transcriptomic Atlas of Retrograde-Labeled Corneal Sensory Afferents in Physiological and Dry Eye Disease Conditions

生理状态与干眼状态下逆行标记角膜感觉传入神经元的单细胞转录组图谱

Corneal Sensitivity and Neuropathic Pain Features in Patients with Persistent 'Dry Eye Disease' Symptoms Seeking Additional Opinions: Two Case Series from a Tertiary Center

三级医院久治不愈干眼症状患者的角膜敏感度与神经病理性疼痛特征:两项病例系列研究

A Pilot Study Exploring the Relationship Between Lipid Layer Thickness and Ocular Surface Disease Index in Non-Dry Eye and Mild Dry Eye Subjects

非干眼与轻度干眼人群泪膜脂质层厚度与眼表疾病指数相关性的初步研究

Correlation of corneal findings to the novel non-contact esthesiometer and Cochet-Bonnet in neurotrophic keratopathy and dry eye disease patients

神经营养性角膜病变及干眼患者角膜检测指标与新型非接触式知觉计、Cochet-Bonnet 知觉计的相关性

The relationship between dry eye traits measured by an automated ocular surface analyser, diagnosis and severity of symptoms in a population-based cohort

基于人群队列的自动化眼表分析仪干眼指标与临床诊断、症状严重程度的关联

Associations Between Serum Glutamate Levels, Signs and Symptoms of Dry Eye Disease, and Corneal Nerves

血清谷氨酸水平与干眼体征、症状及角膜神经的相关性

Influence of palpebral fissure height alterations on non-invasive assessment of tear film in dry eye disease

睑裂高度变化对干眼泪膜无创检测结果的影响

A novel microfluidic technology for tear fluid rheological analysis delivers highly accurate and repeatable diagnosis and subtyping of dry eye disease

新型微流控泪液流变分析技术用于干眼精准诊断及分型

Profile and Severity of Meibomian Gland Dysfunction: Real-world Data from the Save Sight Dry Eye Registry

睑板腺功能障碍患病特征与严重程度:Save Sight 干眼真实世界登记研究

Endotyping Dry Eye Disease: From Clinical Phenotypes to Molecular Targets

干眼内型分类:从临床表型到分子治疗靶点

Symptomatic dry eye patients at baseline have distinct characteristics and clinical course: an electronic health record-based analysis

基线有症状干眼患者的特征及临床病程:基于电子病历的分析

Comparative analysis of diagnostic tests in dry eye disease: Insights from the Save Sight Dry Eye Registry

干眼各项诊断检查的对比分析:Save Sight 干眼登记库研究

Elevated Expression of IL-18 and Histone-NETosis Markers in Aqueous-Deficient and Evaporative Dry Eye Disease

IL-18 及组蛋白 NETosis 标志物在水液缺乏型与蒸发过强型干眼中的高表达

Benchmarking Clinical Definitions of Dry Eye Using AI-Driven Meibography Analysis

基于人工智能睑板腺成像分析建立干眼临床定义基准

Corneal Microneuromas in Dry Eye Disease: Clinical Risk Factors and Association with Immune Cell Activation

干眼患者角膜微神经瘤:临床危险因素及与免疫细胞活化的关联

AI-augmented approaches for dry eye diagnosis from meibography images

基于人工智能的睑板腺影像干眼辅助诊断技术

DryEyeIQ Agent: An Autonomous AI Clinical Copilot for Primary Dry Eye Disease Management

DryEyeIQ 智能助手:基层干眼诊疗自主人工智能辅助系统

Clinical Features and Tear Film Lipid Profiling in Dry Eye Disease Using Mass Spectrometry

基于质谱技术的干眼临床特征与泪膜脂质谱分析

Comparison of Clinically Validated Grading Scores and Quantified Area of Meibomian Gland Loss Using Novel Dry Eye Assessment Device

新型干眼检测设备对睑板腺缺失量化面积与临床分级评分的对比验证

Regional Analysis of Meibomian Gland Dysfunction in Upper and Lower Eyelid as Measured by Meibomian Gland Secretion in Patients with Mild and Moderate Symptomatic Dry Eye

轻中度有症状干眼患者上下眼睑睑板腺功能障碍的分区分泌特征分析

Validation of a mobile app for automatic evaluation of blink behavior and maximum blink interval vs. video analysis in dry eye diagnosis

眨眼行为及最大眨眼间隔手机 APP 自动评估技术用于干眼诊断的效度验证:与视频分析对照

Psychological and somatic burden in dry eye disease: A comparison of neuropathic ocular pain versus classical dry eye symptoms and neurotrophic keratopathy

干眼的心理与躯体负担:神经源性眼痛、经典干眼症状与神经营养性角膜病变的对比

Platelet-Derived Growth Factor (PDGF) Isoform Ratio is Associated with Innate Inflammation and Ocular Surface Disease in Severe Tear-Deficient Dry Eye Disease

血小板衍生生长因子亚型比值与重度水液缺乏型干眼固有炎症及眼表病变的关联

Correlation of neurosensory function, tear parameters, and clinical severity in dry eye disease

干眼神经感觉功能、泪液参数与临床严重程度的相关性

Influence of age and sex on corneal sensitivity threshold by Dry Eye Disease status

年龄、性别对不同干眼状态下角膜知觉阈值的影响

Semi-supervised Deep Learning for Conjunctival and Vascular Segmentation in Conjunctival Hyperemia Assessment in Dry Eye Disease Patients

基于半监督深度学习的干眼患者结膜充血影像结膜及血管分割方法

四、各类药物 / 器械 / 物理治疗

是数量最多的临床治疗类别,涵盖:多个在研新药Ⅱ/Ⅲ期临床试验(AZR-MD-001、ST-100、IVW-1001、Motugivatrep、Reproxalap、T2769等)、已上市药物(利福特拉斯系统综述与Meta分析、真实世界研究)、物理治疗(IPL/LLLT联合疗法)、润滑剂与纳米制剂、新型生物疗法、自体血清、益生菌RCT、中药RCT、接触镜、泪点栓及用药依从性研究。

英文标题

中文标题

3-Month Safety Data Outcomes from a Phase 3 Study of AZR-MD-001 0.5% (ASTRO) for the Treatment of Dry Eye Disease and Signs of Meibomian Gland Dysfunction

0.5% AZR-MD-001(ASTRO)治疗干眼及睑板腺功能障碍体征的 Ⅲ 期临床 3 个月安全性结局

Patient-Reported Outcomes of a Supplement in Adults with Dry Eye Disease: A 56-Day In-Home Usage Study

膳食补充剂用于成人干眼的患者报告结局:为期 56 天居家使用研究

Lid Outcomes Following Treatment with AZR-MD-001 0.5% in Contact Lens Wearers with Meibomian Gland Dysfunction and Dry Eye: The ARIES Phase 2 Study

0.5% AZR-MD-001 治疗合并睑板腺功能障碍干眼隐形眼镜佩戴者的眼睑结局:ARIES Ⅱ 期临床研究

Dry Eye Disease Prescribing Patterns: Comparing Evaporative vs. Aqueous-Deficient Dry Eye

干眼临床用药处方特征:蒸发过强型与水液缺乏型干眼对比分析

The Pre-clinical Comparison of Pottasium Hyaluronate and Sodium Hyalunonate in Alleviating Dry Eye Disease

透明质酸钾与透明质酸钠缓解干眼的临床前对比研究

PLL-g-PEG eye drops in chronic dry eye patients: functional and dynamic assessment results

PLL-g-PEG 滴眼液用于慢性干眼患者:功能学与动态评估结果

Changes in ocular surface temperature and conjunctival blood flow after punctal plug treatment in patients with dry eye

泪点栓塞治疗后干眼患者眼表温度及结膜血流变化

Early Response to treatment with lifitegrast ophthalmic solution in patients with dry eye disease: a post hoc analysis of two randomized trials

利福特拉斯滴眼液治疗干眼的早期疗效反应:两项随机临床试验的事后分析

Enhanced symptomatic relief and patient satisfaction with T2769 in moderate to severe dry eye disease.

T2769 可提升中重度干眼症状缓解效果与患者满意度

IVW-1001 ophthalmic eyelid wipe to treat dry eye patients, a Phase 1/2a Trial

IVW-1001 眼睑擦拭剂治疗干眼的 Ⅰ/2a 期临床试验

Spectroscopic analysis of human meibum lipid composition after low-level light therapy in individuals with dry eye disease

低能量光治疗后干眼患者睑板腺脂质成分的光谱分析

A Randomized Double-Masked Vehicle Controlled Multi-Center Phase 3a Dry Eye Disease (DED) Trial to Test Safety & Efficacy of ST-100, a Collagen Mimetic Peptide Therapeutic

胶原模拟肽药物 ST-100 治疗干眼的多中心随机双盲赋形剂对照 Ⅲa 期临床安全有效性研究

What Drives Dry Eye Treatment Decisions? A Survey of Clinician Priorities

干眼治疗决策的影响因素:临床医师诊疗优先级调查

Phase 2b Dose Optimization Study of IVW-1001 Ophthalmic Eyelid Wipe for Dry Eye Disease

IVW-1001 眼睑擦拭剂治疗干眼的 Ⅱb 期剂量优化研究

Reengineering a Dry Eye Management App as a Flexible, Browser-Based Tool for Clinical and Remote Use

干眼管理 APP 重构:适配临床及远程应用的轻量化网页版工具开发

Oral Probiotic NVP-2201 Improves Eye Fatigue and Dry Eye Symptoms: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

口服益生菌 NVP-2201 改善视疲劳与干眼症状:随机双盲安慰剂对照临床试验

Adherence to topical therapy in dry eye disease: a pilot study integrating ABC/EMERGE metrics with clinical and patient-reported determinants.

干眼局部用药依从性研究:结合 ABC/EMERGE 评估指标与临床及患者报告影响因素的初步探索

Effect of Triple Therapy Combined with Low-Level Light Therapy and Intense Pulsed Light on Evaporative Dry Eye.

三联疗法联合低能量光与强脉冲光治疗蒸发过强型干眼的疗效

Autologous serum ocular inserts for treatment of dry eye disease

自体血清眼用植入剂治疗干眼

Efficacy of in situ gelling Collagen-based “Tough” Punctal Plugs on Lacrimal Obstruction for Dry Eye Disease

原位凝胶胶原型高强度泪点栓治疗干眼泪道阻塞的疗效

Pre-Clinical Investigation of Novel Ocular Nanoemulsions for Dry Eye

新型眼用纳米乳制剂治疗干眼的临床前研究

Propylene Glycol–Hydroxypropyl Guar–Hyaluronic Acid Nanoemulsion Eye Drops for Irritated and Tired Dry Eye Symptom Relief

丙二醇 - 羟丙基瓜尔胶 - 透明质酸纳米乳滴眼液缓解眼干涩疲劳刺激症状

Therapeutic Effects of RCI001 on Mucin Restoration and Tear Film Stability in Dry Eye Disease

RCI001 对干眼黏蛋白修复及泪膜稳定性的治疗作用

Understanding Eye Drop Nonadherence in Glaucoma and Dry Eye Disease: A Mixed-Methods Study

青光眼与干眼患者滴眼液用药不依从性的影响因素:混合方法研究

A new Travoprost formulation containing hyaluronic acid improves ocular penetration while reducing systemic exposure and dry eye signs in preclinical studies

含透明质酸的新型曲伏前列素制剂临床前研究:提升眼内渗透性、减少全身暴露并改善干眼体征

Development of stable PACAP analogs as novel therapeutic agents for dry eye disease

稳定型 PACAP 类似物作为干眼新型治疗药物的研发

WITHDRAWN_Drought to Dew: Exploring Novel Therapeutic Targets in Dry Eye Disease Models

已撤回研究|从干涩到润泽:干眼模型新型治疗靶点探索

AZR-MD-001 0.5% Significantly Improves Meibomian Glands Yielding Liquid Secretions with Clinically Meaningful Benefit Across the Dry Eye Disease Spectrum

0.5% AZR-MD-001 可显著改善睑板腺液态分泌功能,对各类型干眼均有临床获益

Preclinical evaluation of a lubricin-inspired synthetic diblock polymer eye drops for the treatment of dry eye disease

仿润滑素合成双嵌段聚合物滴眼液治疗干眼的临床前评价

Evaluating the protection of commercially available ocular lubricants on human corneal epithelial cells in dry eye disease states

市售眼用润滑剂对干眼状态下人角膜上皮细胞的保护作用评价

Pooled Fluorescein Staining Results from Two Dry Eye Disease Trials with Reproxalap, a Novel RASP Modulator for the Treatment of Dry Eye Disease

新型 RASP 调节剂 Reproxalap 两项干眼临床试验的汇总荧光素染色结局

Physician perspectives on the clinical use of concomitant perfluorohexyloctane and lifitegrast in dry eye disease management: Results from a nationwide survey

临床医师对全氟己基辛烷联合利福特拉斯治疗干眼的应用观点:全国问卷调查结果

Development of an In-Situ Forming Lubricating Ocular Bandage to Alleviate Symptoms of Dry Eye

原位成型润滑眼用绷带用于缓解干眼症状的研发

Randomized placebo-controlled trial shows efficacy of Chinese herb in women with post-menopausal dry eye

随机安慰剂对照试验证实中药对绝经后女性干眼有效

Topical lifitegrast therapy for dry eye disease: a systematic review and meta-analysis

局部利福特拉斯治疗干眼的系统综述与 Meta 分析

Modulation of the Biological and Physical Properties of Hyaluronic Acid Mixtures for Dry Eye Disease

透明质酸复合制剂理化及生物学性能的调控及其在干眼中的应用

Long-term Safety and Efficacy of Motugivatrep, a TRPV1 Antagonist, in Dry Eye Patients

TRPV1 拮抗剂 Motugivatrep 治疗干眼的长期安全性与有效性

五、特殊人群

涵盖:糖尿病相关干眼(含GLP-1受体激动剂专题)、各类术后干眼(白内障/玻璃体切割/屈光手术/玻璃体腔注射术后)、儿童干眼(本届新兴重点专题,含问卷开发/生物标志物/危险因素多篇)、自身免疫性干眼(干燥综合征/类风湿关节炎/GVHD/自身免疫性感觉表型)、老年及年龄相关干眼、特殊病因(遗传性脱髓鞘神经病、航天员)等。

英文标题

中文标题

Association of Glycemic Control with Ocular Pain Among Patients with Dry Eye and Proliferative Diabetic Retinopathy

血糖控制水平与合并增殖性糖尿病视网膜病变干眼患者眼部疼痛的相关性

Effects of Different Treatment Modalities on Dry Eye Severity in Diabetic Retinopathy Patients

不同治疗方案对糖尿病视网膜病变患者干眼严重程度的影响

Outcomes of Cataract Surgery in Patients with Dry Eye Disease

干眼患者白内障手术的临床结局

Association Between HbA1c and BMI with Dry Eye Severity Among Patients with PDR

糖化血红蛋白、体质指数与增殖性糖尿病视网膜病变患者干眼严重程度的相关性

Post-vitrectomy dry eye: A prospective study of ocular surface changes and associated risk factors

玻璃体切割术后干眼:眼表改变及相关危险因素的前瞻性研究

Efficacy of a New Pediatric Dry Eye Questionnaire and Its Comparison to a Modified Ocular Surface Disease Index

新型儿童干眼问卷的有效性评价及其与改良眼表疾病指数的对比

Prospective Validation of A Prediction Model to Screen Dry Eye Patients for Sjogren's Disease

干眼患者筛查干燥综合征预测模型的前瞻性验证

Tear film response to varenicline nasal spray in dry eye disease associated with Sjogren’s disease assessed by high-resolution Tear Film Imager

基于高分辨率泪膜成像仪评估伐尼克兰鼻喷剂对干燥综合征相关性干眼泪膜的影响

Potential biomarkers for Pediatric dry eye disease identified by tear cytokines

基于泪液细胞因子筛选儿童干眼潜在生物标志物

Lactoferrin as an Effective Treatment for Alleviating Dry Eye Symptoms Following Refractive Surgery: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

乳铁蛋白缓解屈光术后干眼症状的疗效:随机双盲安慰剂对照临床试验

Characterizing the Conjunctival Microbiome in Dry Eye Secondary to Rheumatoid Arthritis

类风湿关节炎继发性干眼的结膜微生物组特征分析

Bridging the Gap: From Adult Tools to Pediatric Solutions in Dry Eye Disease

弥合临床差距:干眼评估从成人方案到儿童适用方案的转化

Corneal Sensitivity and Dry Eye Symptoms in Hereditary Demyelinating Neuropathies

遗传性脱髓鞘神经病变患者的角膜敏感度与干眼症状

Repeatability of Pediatric Dry Eye and Modified OSDI Assessments in Children Aged 6–17

6–17 岁儿童干眼及改良眼表疾病指数评估的可重复性研究

Development and Evaluation of Repeatability of Pediatric Dry Eye Questionnaire in Children Aged 6 to <18 Years

6 至 18 岁儿童干眼问卷的编制及评估可重复性验证

Sensory Phenotypes Reveal Distinct Clinical Profiles in Autoimmune-Associated Dry Eye Disease

感觉表型揭示自身免疫相关性干眼的不同临床特征

Preoperative and postoperative treatment with perfluorohexyloctane ophthalmic solution in patients undergoing cataract surgery: effects on signs and symptoms of dry eye disease

围手术期全氟己基辛烷滴眼液对白内障患者干眼体征及症状的影响

Pediatric Dry Eye: Risk Factors and Challenges in Diagnosis

儿童干眼:危险因素与临床诊断挑战

Real-world characteristics of autoimmune patients with dry eye disease treated with lifitegrast: Insights from the AAO IRIS® Registry

利福特拉斯治疗自身免疫性干眼的真实世界特征:美国眼科学会 IRIS 登记库数据分析

Lid, Conjunctival, and Corneal Outcomes Following Treatment with AZR-MD-001 0.5% vs. Vehicle in Contact Lens Wearers who have Meibomian Gland Dysfunction and Dry Eye: The ARIES Phase 2 Study

0.5% AZR-MD-001 与赋形剂对比治疗合并睑板腺功能障碍干眼隐形眼镜佩戴者的眼睑、结膜及角膜结局:ARIES Ⅱ 期研究

Effects of preoperative treatment with perfluorohexyloctane ophthalmic solution on refractive outcomes in patients with dry eye disease undergoing cataract surgery

白内障术前应用全氟己基辛烷滴眼液对干眼患者屈光术后效果的影响

Drug-Induced Dry Eye in Children and Adolescents: A FAERS Disproportionality Analysis

儿童及青少年药物性干眼:基于 FAERS 数据库的不相称性分析

Pediatric Dry Eye: An Emerging Concern

儿童干眼:日益受到关注的临床问题

Associated Factors for Dry Eye Symptoms in Children Aged 5 to 17 Years

5–17 岁儿童干眼症状的相关影响因素

Prospective Pilot Randomized Controlled Study of Mini Scleral Lenses versus Rigid Gas Permeable Lenses in Irregular Cornea with Dry Eye

迷你巩膜镜与硬性透气性角膜接触镜用于合并干眼不规则角膜的前瞻性初步随机对照研究

Assessing Autonomic Dysfunction in Autoimmune Dry Eye Disease Using Infrared Thermography

红外热成像技术评估自身免疫性干眼的自主神经功能障碍

Tear Osmolarity and Meibomian Gland Morphology as Predictors of Postoperative Dry Eye After Refractive Surgery

泪液渗透压与睑板腺形态作为屈光术后干眼的预测指标

Association of GLP-1 Receptor Agonist Use With Dry Eye Severity in Adults With Proliferative Diabetic Retinopathy

GLP-1 受体激动剂使用与增殖性糖尿病视网膜病变成人患者干眼严重程度的相关性

Glucagon-like peptide-1 receptor agonists and risk of dry eye disease

胰高血糖素样肽 - 1 受体激动剂与干眼发病风险

The Association between the Development of Corneal Abrasions Post Intravitreal Injections and Dry Eye Disease

玻璃体腔注射术后角膜上皮缺损发生与干眼的相关性

第二部分  ARVO 2026 干眼病研究趋势分析

2.1 六大核心趋势

趋势一:单细胞与空间转录组学重塑基础研究范式

本届至少6篇文章运用单细胞RNA测序(scRNA-seq)或空间转录组技术,从单细胞分辨率解析干眼发病机制。代表性成果包括:自身免疫性干眼眼表微环境的单细胞转录组反卷积分析、单细胞转录组揭示丁酸盐对自身免疫性干眼的抗炎作用、生理状态与干眼状态下逆行标记角膜感觉传入神经元的单细胞转录组图谱、衰老人泪腺的空间转录组分析,以及单细胞转录组测序揭示泪腺腺泡细胞氧化应激诱发干眼的机制。这一趋势标志着干眼病基础研究正从组织整体水平迈向单细胞分辨率,有望发现高精度细胞治疗靶点

趋势二:AI与数字化诊断快速崛起

AI辅助诊断是本届最显著的新兴亮点,相关文章达8篇以上。涵盖:基于人工智能睑板腺成像分析建立干眼临床定义基准、基于人工智能的睑板腺影像干眼辅助诊断技术、半监督深度学习用于干眼患者结膜充血影像分割、基于双向长短期记忆网络的眨眼时相分割、眨眼行为手机APP自动评估技术验证、DryEyeIQ自主AI临床辅助系统,以及多项机器学习预测模型(血清代谢标志物、OSDI6预测)。AI正在从辅助检测走向全流程临床决策支持。

趋势三:儿童干眼病成为新兴重点专题

本届专门针对儿童干眼病的文章达8篇,是近年ARVO最集中的儿科干眼病专题,内容覆盖:新型儿童干眼问卷的有效性评价及其与改良眼表疾病指数的对比、6至18岁儿童干眼问卷的编制及评估可重复性验证、6-17岁儿童干眼及改良OSDI评估的可重复性研究、基于泪液细胞因子筛选儿童干眼潜在生物标志物、5-17岁儿童干眼症状的相关影响因素、儿童及青少年药物性干眼(FAERS数据库)、干眼评估从成人方案到儿童适用方案的转化,以及儿童干眼:日益受到关注的临床问题。随着屏幕使用低龄化加剧,儿童眼表健康正受到前所未有的重视。

趋势四:GLP-1受体激动剂与干眼——新兴交叉热点

司美格鲁肽等GLP-1受体激动剂的全球使用量激增,本届出现2篇专题研究:GLP-1受体激动剂使用与增殖性糖尿病视网膜病变成人患者干眼严重程度的相关性,以及胰高血糖素样肽-1受体激动剂与干眼发病风险。这一发现具有重要的临床警示意义,同时也为干眼的药物性风险评估提供了新视角,有望成为近期高关注度的交叉研究方向。

趋势五:多条在研新药管线集中披露Ⅱ/Ⅲ期数据

本届至少有以下在研药物或制剂发布重要临床数据:

  • AZR-MD-001 0.5%——Ⅲ期ASTRO研究3个月安全性数据 + Ⅱ期ARIES研究眼睑/结膜/角膜多终点数据,多篇报告覆盖MGD与干眼全谱

  • ST-100胶原模拟肽——多中心随机双盲赋形剂对照Ⅲa期临床安全有效性研究

  • IVW-1001眼睑擦拭剂——Ⅰ/2a期临床试验 + Ⅱb期剂量优化研究

  • Motugivatrep(TRPV1拮抗剂)——长期安全性与有效性数据

  • Reproxalap(新型RASP调节剂)——两项干眼临床试验汇总荧光素染色结局

  • T2769——中重度干眼症状缓解效果与患者满意度

  • RCI001——黏蛋白修复及泪膜稳定性治疗作用

上述管线覆盖抗炎、神经调节(TRPV1拮抗)、黏蛋白修复、RASP调节及物理化学润滑等多个机制,干眼病药物研发正进入多赛道并进的丰收期。

趋势六:环境因素研究升温,跨学科视野显著拓宽

流行病学研究呈现鲜明的环境健康视角:长期黑碳暴露与干眼发病风险(病例对照研究)、居住地绿地覆盖率调节干眼与环境温度的关联(北京病例交叉研究)、二手烟暴露对干眼患病率及严重程度的影响(香港人群研究)、职场人群干眼与电子屏幕使用的患病率及相关性。同时,遗传流行病学方向出现多基因风险评分(PRS)预测干眼易感性及双生子队列遗传度研究,标志着干眼病流行病学从单一危险因素走向暴露组与遗传组学并重的综合研究框架。

2.2 值得关注的新兴交叉方向

  • -眼轴研究:口服益生菌NVP-2201改善视疲劳与干眼症状(随机双盲安慰剂对照RCT)、嗜热链球菌iHA318缓解干眼症状的多模态机制(神经调控、炎症小体抑制及黏蛋白唾液酸化)

  • 遗传学与精准医学:干眼的遗传易感性多基因风险评分研究(迈阿密退伍军人队列)、基于眼表分析仪的干眼表型遗传度双生子研究

  • 微生物组与干眼:类风湿关节炎继发性干眼的结膜微生物组特征分析

  • 无细胞生物疗法:STLR-201修复干眼小鼠角膜完整性(两项研究),作为治疗干燥综合征干眼的无细胞生物疗法

  • 神经源性干眼与神经病理性眼痛:多篇文章形成神经诊断小专题,涵盖角膜微神经瘤、角膜敏感度、神经感觉功能及神经病理性眼痛与经典干眼的比较

  • 航天医学:首次出现定量模型评估航天辐射对航天相关性干眼综合征(SADES)的剂量-反应关系

2.3 小结

ARVO 2026 干眼病研究整体呈现以下面貌:

  • 基础层:高维组学化——单细胞/空间转录组成为标配,深入解析免疫、神经与代谢机制

  • 诊断层:AI数字化——从图像分析到临床辅助决策,AI工具链正在形成

  • 治疗层:管线多元化——多个Ⅱ/Ⅲ期临床数据集中披露,新机制药物涌现

  • 特殊人群层:儿童化与代谢病化——儿童干眼和糖尿病/GLP-1相关干眼成为新焦点

  • 流行病学层:环境与遗传并重——暴露组学与多基因风险评分共同构建病因框架

干眼病正从过去以人工泪液为主的局限认知,演变为横跨眼科、免疫学、神经科学、代谢病学与数字医学的综合性研究领域,未来的精准治疗体系呼之欲出。


 
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