编者按：2026年国际血栓与止血学会（ISTH）大会将于7月11日至15日在浪漫之都法国巴黎盛大召开。作为全球血栓与止血领域的顶级学术盛会，本届大会将汇聚世界各地数千名顶尖专家，共同展示前沿研究成果，探讨改善患者护理的最新临床应用。备受瞩目的是，今年有超35项中国研究脱颖而出成功入选口头报告，涵盖基因治疗、免疫性血小板减少症发病机制、新型抗栓药物研发、多组学风险预测及临床诊疗标准化等多个领域。本文特梳理如下，带您直击国际学术最前沿。

摘要号：LB 01.2

汇报者：Dongxing Xie（中南大学湘雅医院）汇报时间：Sunday, 12 July • 11:30 - 11:45 CEST汇报地点：Paris Ballroom

摘要号：SOA 14.3

汇报者：Bo Zhou（中国科学院分子细胞科学卓越创新中心）汇报时间：Monday, 13 July • 08:50 - 09:15 CEST汇报地点：S04

标题：Traumatic Brain Injury-Induced Coagulopathy: A Mouse Model Study

中文标题：创伤性脑损伤诱发的凝血病：一项小鼠模型研究

标题：Part I: Advances in the diagnosis and management of TTP

中文标题：第一部分：TTP诊断与管理的进展

标题：Clusterin-mediated stabilization of VWF in plasma

中文标题：簇集蛋白介导的血浆中血管性血友病因子（VWF）稳定作用

标题：Standardization processes and regulatory requirements of gene therapy in China, with a focus on studies in adolescents

中文标题：中国基因治疗的标准化流程与监管要求，重点关注青少年人群研究

标题：CLOT: A Clot Learning and On-Guard Tracking system for Stratifying Blood Clots Prior to Coagulation Assays

中文标题：CLOT：一种用于凝血检测前血液凝块分层的凝块学习与实时追踪系统

标题：Hepatic FGFR-ERK-HRG axis regulates heparin-induced thrombocytopenia with thrombosis

中文标题：肝脏 FGFR-ERK-HRG 轴调节肝素诱导的血小板减少症伴血栓形成

标题：Knowledge-Attitude-Practice Behavioral Reinforcement by Smart Guidance Engine for Venous ThromboEmbolism: a randomized controlled trial

中文标题：智能指导引擎强化静脉血栓栓塞症“知识-态度-实践”行为的随机对照试验

标题：A Novel AAV-Mediated Gene Therapy for Hemophilia A Using a FVIII-Mimetic Trispecific VHH antibody

中文标题：一种利用FVIII模拟三特异性VHH抗体的AAV介导血友病A新型基因疗法

标题：Long-Term Efficacy and Safety of Lower Dose AAV8-FVIII Gene Therapy in Chinese Patients with Severe Hemophilia A

中文标题：低剂量AAV8-FVIII基因治疗在中国重型血友病A患者中的长期疗效与安全性

标题：Efficacy and safety of Dalnacogene Ponparvovec (BBM-H901) gene therapy in adults with moderate to severe hemophilia B: pooled analysis of long-term follow-up data from phase I/II/III trials in China

中文标题：Dalnacogene Ponparvovec（BBM-H901）基因治疗在中重度血友病B成人患者中的疗效与安全性：基于中国I/II/III期临床试验长期随访数据的汇总分析

标题：Short-term performance of bleeding risk scores in anticoagulated older patients with acute pulmonary embolism

中文标题：出血风险评分在抗凝治疗的老年急性肺栓塞患者中的短期预测效能

标题：Oxylipin 12-HETE inhibits platelet activation and mitigates acute myocardial infarction via a PPARα-dependent pathway

中文标题：氧脂质12-HETE通过PPARα依赖性途径抑制血小板活化并减轻急性心肌梗死

标题：Protein disulfide isomerase-related protein (PDIr) is a critical extracellular negative regulator of arterial thrombosis

中文标题：蛋白质二硫键异构酶相关蛋白（PDIr）是动脉血栓形成的关键胞外负向调节因子

标题：An element preceding the mechanosensory domain of GPIbα suppresses GPIb-IX signaling

中文标题：GPIbα机械感应结构域上游的一段元件抑制GPIb-IX信号传导

标题：Integrated RNA and Protein Functional Analysis Reveals Misclassified PROC Variants and Enables Splice-Directed Correction

中文标题：整合的RNA与蛋白功能分析揭示了被误分类的PROC基因变异，并实现了基于剪接的靶向纠正

标题：Chronic thromboembolic pulmonary disease after pulmonary embolism: Insights from the CURES study

中文标题：肺栓塞后的慢性血栓栓塞性肺疾病：来自CURES研究的启示

标题：Targeting the CD38-NAD⁺ axis alleviates antibody-driven cytopenia in autoimmune disorders without inducing broad immunosuppression

中文标题：靶向CD38-NAD⁺轴可在不引起广泛免疫抑制的情况下，缓解自身免疫性疾病中抗体介导的血细胞减少症

标题：A Novel Classification Approach for Immune Thrombocytopenia with Distinct Treatment Sensitivities

中文标题：一种针对具有不同治疗敏感性的免疫性血小板减少症的新型分类方法

标题：Relation of Thrombopoietin and T Cell Subsets in Children with Chronic Immune Thrombocytopenia at Diagnosis

中文标题：慢性免疫性血小板减少症患儿初诊时血小板生成素与T细胞亚群的关系

标题：A High-Throughput Vortex Shear SlipChip for Personalized Assessment of Thrombus Function under Pathological Flow Conditions

中文标题：一种用于在病理血流条件下高通量评估血栓功能及实现个性化检测的涡流剪切滑移芯片

标题：The bitter taste receptor T2R14 regulates CD4+ T cell differentiation in immune thrombocytopenia

中文标题：苦味受体T2R14调控免疫性血小板减少症中的CD4+ T细胞分化

标题：Lysophosphatidylcholine-induced macrophage polarization imbalance and functional dysregulation in immune thrombocytopenia

中文标题：溶血磷脂酰胆碱诱导免疫性血小板减少症中的巨噬细胞极化失衡与功能失调

标题：Aberrant Macrophage Polarization in Immune Thrombocytopenia Driven by PI3K-AKT Pathway

中文标题：PI3K-AKT通路驱动的免疫性血小板减少症中巨噬细胞异常极化

标题：Reduced SRSF1 expression promotes exon skipping of LCK to attenuate Treg induction in Immune Thrombocytopenia

中文标题：SRSF1表达降低促进LCK基因外显子跳跃，从而减弱免疫性血小板减少症中的调节性T细胞诱导

标题：A Novel Fibrinogen Variant Fg-Zhongshan (FGA p.Arg459Cys) Escapes Routine Coagulation Testing and Promotes Thrombosis via Impaired Fibrinolysis

中文标题：一种新型纤维蛋白原变异体Fg-Zhongshan（FGA p.Arg459Cys）可逃避常规凝血检测，并通过损害纤溶功能促进血栓形成

标题：Genotype–Phenotype Correlation in Pediatric Congenital Thrombotic Thrombocytopenic Purpura: A Single-Center Cohort from Beijing Children’s Hospital

中文标题：儿童先天性血栓性血小板减少性紫癜的基因型-表型相关性：来自北京儿童医院的单中心队列研究

标题：Proteomics Augmented Models Improve Risk Prediction for Ischemic Stroke, Myocardial Infarction, and Venous Thromboembolism

中文标题：蛋白质组学增强的模型可提升缺血性卒中、心肌梗死及静脉血栓栓塞症的风险预测能力

标题：Large-scale Plasma Proteomics Association and Genetic Prioritization of Candidate Drug Targets for Thrombotic Events

中文标题：大规模血浆蛋白质组学关联分析及血栓事件候选药物靶点的遗传学优先排序

标题：Multi-omics Elucidates Extracellular Matrix-Driven Vascular Remodeling in Chronic Thromboembolic Pulmonary Hypertension

中文标题：多组学阐明慢性血栓栓塞性肺动脉高压中细胞外基质驱动的血管重塑

标题：High-molecular-weight VWF amplifies microthrombosis and complement effector activity in an LPS-induced TMA model

中文标题：高分子量血管性血友病因子（VWF）在脂多糖（LPS）诱导的血栓性微血管病（TMA）模型中放大微血栓形成与补体效应活性

标题：PK/PD-Guided Individualized Emicizumab Dosing in Pediatric Hemophilia A: A Prospective Cohort Study

中文标题：药代动力学/药效学（PK/PD）指导下的儿童A型血友病艾美赛珠单抗个体化给药：一项前瞻性队列研究

标题：Disruption of the β3-Src interaction exhibits safe and effective antithrombotic and immunomodulatory effects

中文标题：破坏β3-Src相互作用展现出安全且有效的抗血栓与免疫调节作用

标题：Single-cell Transcriptomic Profiling Reveals Niche Megakaryocyte-biased Leukemic Hematopoiesis in Pediatric Acute Megakaryoblastic Leukemia

中文标题：单细胞转录组图谱揭示儿童急性巨核细胞白血病中微环境巨核细胞偏向的白血病造血

标题：Characterization and Prothrombotic Mechanism of extracellular vesicles in Patients with Thrombotic Thrombocytopenic Purpura

中文标题：血栓性血小板减少性紫癜患者细胞外囊泡的特征分析及其促血栓形成机制

标题：Spatially Resolved Proteomics Reveals the Temporal Remodeling of Murine Venous Thrombi

中文标题：空间分辨蛋白质组学揭示小鼠静脉血栓的时序性重塑